PharmaSizer

Pharmaceutical Particle Size Analysis Designed for Modern Manufacturing

PharmaSizer is Xoptix's dedicated in-process particle size analyser developed specifically for pharmaceutical, food, and specialist powder manufacturing environments. Combining proven laser diffraction technology with hygienic design principles, PharmaSizer delivers real-time particle size measurement directly within the production process, enabling manufacturers to improve product quality, optimise yield, and maintain process consistency. Built around more than 30 years of particle sizing experience, PharmaSizer provides accurate and reliable measurement from laboratory-scale development through to full-scale production, helping manufacturers gain complete control over critical particle size specifications.

Engineered for Pharmaceutical and Food Applications

Unlike conventional process particle size analysers adapted from industrial designs, PharmaSizer has been engineered specifically for hygienic manufacturing environments. The XI220P model features a fully stainless-steel 316L construction with pharmaceutical-grade tri-clamp connections throughout. All product-contact components are manufactured from certified materials and individually marked for full material traceability. FFKM sealing technology provides exceptional chemical resistance, ensuring compatibility with demanding cleaning procedures and aggressive process environments. The result is a robust and highly cleanable system ideally suited to pharmaceutical powders, food ingredients, nutraceuticals, specialty chemicals, and other high-value products.

Real-Time Particle Size Monitoring

Particle size directly influences product quality, dissolution rate, flowability, blend uniformity, and final product performance.PharmaSizer continuously monitors particle size during production, allowing operators to detect process changes immediately rather than waiting for laboratory results. Real-time measurement enables faster decision making, improved process stability, reduced waste, and increased production efficiency.

Typical benefits include:
1.Improved product consistency and quality
2.Redused Process Veriability
3.Increased process throughput
4.Reduced energy consumption
5.Lower reject rates
6.Reduced manufacturing costs
7.Faster return on investment

Continuous measurement provides valuable process intelligence that can be integrated directly into plant control systems for advanced process optimisation. Designed for Fast Product Changeovers A unique removable sample path allows operators to exchange the complete sampling cell in less than one minute without disturbing instrument alignment. This innovative design significantly reduces downtime during product changeovers and cleaning operations. Unlike many competing systems, PharmaSizer does not require time-consuming optical realignment after maintenance or cleaning procedures.

Hygienic Monobloc Construction

Precision-machined 316L stainless steel measurement cavity with smooth hygienic surfaces for easy cleaning, reduced powder retention, and reliable operation in pharmaceutical and food manufacturing environments.

Hygienic Monobloc Measurement Cell The PharmaSizer measurement cell is machined from solid 316L stainless steel and designed specifically for pharmaceutical and food manufacturing environments. The smooth internal surfaces minimise product build-up, eliminate dead zones, and facilitate rapid cleaning between batches. The open monobloc design provides excellent accessibility for inspection, cleaning, and maintenance while maintaining the robustness required for continuous industrial operation.
All product-contact surfaces are manufactured to pharmaceutical standards and are fully compatible with hygienic cleaning procedures. Designed for Cleanability The measurement cavity features smooth polished surfaces and a crevice-minimised design to reduce powder retention and cross-contamination risks. This makes PharmaSizer particularly suitable for applications involving high-value products, frequent product changeovers, and stringent cleaning requirements.
Every product-contact component can be fully traced back to its material source, supporting GMP requirements and validation procedures. Combined with pharmaceutical-grade sealing systems and hygienic tri-clamp connections, PharmaSizer provides a particle size measurement solution suitable for regulated manufacturing environments.

Features

1.316L stainless steel construction
2.Smooth hygienic internal surfaces
3.Reduced powder retention
4.Minimised dead zones and crevices
5.Easy visual inspection
6.Fast cleaning and product changeovers
7.Full material traceability
8.GMP-friendly design
9.Suitable for pharmaceutical and food applications
10.Designed for continuous operation

Industries and Applications

Pharmaceutical Manufacturing
Active Pharmaceutical Ingredients (APIs), Dry Powder Inhalers (DPI),
Pharmaceutical milling and micronisation, Continuous manufacturing processes,
Pharmaceutical powder blending

Food and Nutrition
Infant formula, Food ingredients, Milk powders, Protein powders, Egg Powders
Starches, Sugar and sweeteners, Coffee processing and grinding, Cocoa and chocolate ingredients, Food additives and premixes,Tea powder, Nutraceutical ingredients

Life Sciences and Healthcare
Nutraceuticals, Dietary supplements, Functional food ingredients, Medical powders

Fine and Specialty Chemicals
High-value powders, Specialty chemicals, Performance materials, Advanced formulations

Research and Process Development
Pilot plants, Scale-up facilities, Process optimisation studies, Continuous process monitoring

Exceptional Stability and Measurement Confidence

At the heart of PharmaSizer is Xoptix's unique optical architecture. Rather than mounting optics on an optical bench, the complete measurement system is built inside the optical bench itself. This provides exceptional mechanical stability and ensures that changes in measurement results reflect actual process changes rather than instrument movement or environmental influences. The result is highly repeatable particle size data even in demanding manufacturing environments.